GUIDE.MRD is a people-centered precision oncology project designed to improve the utility and clinical implementation of ctDNA as biomarker of MRD to predict clinical response and choice of multi-modal therapy for patients with solid tumour malignancies. Partners from academic, medical technology, pharmaceutical and patient advocacy sectors assembled the project objectives to be fully pertinent and aligned with HORIZON-JU-IHI-2022-01, Call 1, Topic 3 “Personalized oncology: innovative people centered, multi-modal therapies against cancer”.